Route 16 circulates from the Greenbelt Metrorail Station to the New Carrollton Metrorail Station via Greenbelt Road, Good Luck Road, and Riverdale Road. The route serves the Berwyn Heights neighborhood, business/retail along Greenbelt Road and shops in New Carrollton including the Beltway Plaza Shopping Center and Carrollton Shopping Center. Other key stops include Doctors Community Hospital and New Carrollton Branch Library. Riders on the Route 16 enjoy access to the Schrom Hill Recreation Center, Berwyn Heights Town Hall, and Greenbelt Park.
New schedule is in effect to accommodate demand during COVID-19.